The Primorsko-notranjska statistical region had the lowest share of Slovenia’s population in 2022 (2.5%). The region also stood out with the lowest population density (37 persons per square kilometre). Natural increase was negative in 2022 (-3.3 per 1,000 population), while net migration was positive and at 10.5 per 1,000 population the second highest among regions. The share of foreign nationals in the population was 9.1%. Only Osrednjeslovenska and Obalno-kraška had higher shares of foreign nationals. The region stood out with the highest share of men (51.4%). The mean age at death was 79.6 years, the second highest at the regional level. The share of the population aged 0–14 was 15.4%, while the share of the population aged 65 or more was 22.2%. This was one of the three regions with the share of the population aged 80+ higher than 6%. In Goriška, 6.9% of the population was aged 80 or more, in Primorsko-notranjska and Obalno-kraška, the share was 6.1%. It also stood out among the regions with the highest share of married inhabitants, at 47.6%, followed by Goriška (47.5%). 52% of children were born to unmarried mothers, which was the third lowest share. Mothers aged under 25 gave birth to 13% of children in the region, the fourth highest share, and mothers aged 35 or over gave birth to 24% of children, the third highest share among the regions. The share of third-born or higher-order children was 17.4%, behind Goriška (17.5%) and Jugovzhodna Slovenija (19.6%). Among the region's population aged 25–64, 13.0% had basic education or less and 30.3% had tertiary education. Of all 1–5-year-olds, 79.3% were included in kindergartens, which was one of the lowest shares at the regional level.
In 2022, the highest employment rate was recorded in this region: 73.4% of the working age population were in employment. The gap between the employment rate for men (78.6%) and for women (67.5%) was the highest at 11.1 percentage points. 43.5% of persons in employment from this region worked in another statistical region, a large majority of them in Osrednjeslovenska. The share of people who worked outside the region of residence was the second highest after Zasavska (53.1%). Average monthly net earnings were the lowest in the country. They amounted to EUR 1,184, which was EUR 135 less than the national average. The region is among the weakest in terms of the economy. GDP per capita was the third lowest among the regions (EUR 18,783). This region contributed 1.8% to Slovenia's GDP. There were almost 5,000 enterprises operating in the region; each employed on average 3.4 people.
Compared to other regions, the region had one of the highest rates of severe material deprivation (3.7% of persons) and risk of poverty (14.0% of persons). The very low work intensity rate was the second highest; 5.5% of persons aged 0–64 living in households where the adults (aged 18–64) worked less than 20% of their total work potential (expressed in months). On the other hand, the region had one of the lowest shares of population living in overcrowded dwellings (6.3%). Primorsko-notranjska, Goriška and Koroška had the lowest number of convicted persons (adults and juveniles) per 1,000 population (1.4). In terms of the number of passenger cars per 1,000 population (615) and their average age (12.0 years), the region was second. Of the total amount of wastewater generated in this region, 93.5% was treated before discharge into the public sewerage system. This was the fourth highest share among the regions. On average, 403 kilograms of municipal waste were generated per capita, the second lowest amount among the regions.