Regarding the area, Posavska is the second smallest region in Slovenia. Nevertheless, with 968 square kilometres it is twice as large as the smallest region, Zasavska. The Posavska statistical region had about 4% of Slovenia’s population in 2021. The region recorded a natural decrease, while net migration was positive. Total increase was -99 persons. The share of mothers under the age of 20 was the second highest in this region (2.0%). It was the highest in Jugovzhodna Slovenija (2.9%). In 2021, the average age of mothers at first birth was at 28.8 years also the highest in both mentioned regions. The share of the population over 14 years old with tertiary education (20.3%) was below the national average (25.0%), while the share of the population with basic education or less (24.9%) was above the national average (22.2%). Residents of this region assessed their life satisfaction with 7.7 out of 10, the same as the average in the country and the same as in Koroška and Obalno-kraška.

In 2021, the employment rate in the Posavska statistical region (67.5%) was slightly above the national average. The difference between the employment rate for men (72.5%) and the employment rate for women (62.0%) was the highest. More than a third of the persons in employment in the region worked outside the region of residence (35.4%). Average monthly net earnings were EUR 51 below the national average; they amounted to EUR 1,220. GDP per capita was EUR 21,001. The share of people living in overcrowded dwellings was the third highest (15.4%). At 0.3%, the severe material deprivation rate was the lowest at the regional level. In 2021, 498 kg of municipal waste was generated per capita. This was 78 kilograms per capita less than in the Osrednjeslovenska statistical region, where the largest amount of municipal waste per capita was generated. Households in the region were supplied on average 35.3 m3 of water per capita from the public water supply. This was the third lowest quantity at the regional level.