Very good traffic accessibility, fertile river valleys of Sava and Krka, the hilly areas of vineyards and the abundance of water are the characteristics of the second smallest statistical region in Slovenia. The only nuclear power plant in the country and the thermal riviera at the Čatež health resort are its main features.

For environmental protection the Spodnjeposavska region annually allocated only around 0.1% of its gross domestic product. For the same purpose this region in 2011 allocated only 0.3% of total gross fixed capital formation, which is the least among all regions.

In 2012, the employment population ratio in the region was around the national average. It was characterized by the largest difference between the employment rate for men and for women (for men it was 13 percentage points higher than for women). In the same year the highest number of sick leave cases was registered in Spodnjeposavska (122 per 100 persons in employment); they lasted on average almost 20 days. In 2012 the fewest insolvency proceedings were commenced in Spodnjeposavska, only 5 compulsory compositions, bankruptcies and liquidations per 1,000 companies and cooperatives in the region.

General libraries in the Spodnjeposavska region (the same situation was in Podravska) had the fewest members per 1,000 population; in 2012, on average 90 members fewer than in the Goriška region. However, the share of members among the youth was the highest in the country (37%).