Municipality Novo mesto, which is part of the Jugovzhodna Slovenija statistical region, measures 236 km2; this ranks it 20th among Slovene municipalities.

Statistical data for 2012 reveal the following:

In the middle of 2012 about 36,400 people (about 18,150 men and 18,250 women) were living in the municipality, which ranks Novo mesto 6th among Slovene municipalities. The population density was 154 people per square kilometre, which was higher than the national average of 101 people per square kilometre.

The number of live births was higher than the number of deaths, which means that natural increase per 1,000 population in the municipality was positive. It was 3.4 (in Slovenia 1.3). The number of people who moved from the municipality was higher than the number of people who moved into the municipality, so net migration per 1,000 population in the municipality was negative. It was -6. The sum of natural increase and net migration per 1,000 population in the municipality was negative. It was -2.6 (in Slovenia 1.6).

The mean age of people in Novo mesto was 40.5 years, which was lower than the national average (42).

In contrast to most Slovene municipalities, in Novo mesto the number of young people was the same as the number of old people: there were 100 people, aged 65 or more, per 100 people aged 0–14. This ratio shows that the value of the ageing index was lower than the national average of 118. It also shows that the mean age of people in Novo mesto is growing more slowly than in Slovenia as a whole. Data by sex show that the ageing index for women was in all Slovene municipalities higher than the ageing index for men. In Novo mesto – as in most Slovene municipalities – more women were 65+ years old than 14 or less; for men the situation was exactly the opposite.

Novo mesto had 22 kindergartens. They were attended by 1,715 children or 76% of all children aged 1–5, which was more than the national average of 75%. In the school year 2012/2013 basic schools in Novo mesto were attended by about 3,210 pupils, while various upper secondary schools were attended by about 1,470 pupils. There were 60 students and 11 graduates per 1,000 people in the municipality; in Slovenia the averages were 47 per 1,000 and 10 per 1,000, respectively.

Among people aged 15–64 (i.e. working age population) about 60% were persons in employment (i.e. persons in paid employment or self-employed persons), which is more than the national average of 57%.

The registered unemployment rate was 11.1%, which is less than the national average (12%). In contrast to most Slovene municipalities, more men than women were unemployed.

In Novo mesto, average monthly gross earnings per person employed by legal persons were about 12% higher than the annual average of monthly earnings for Slovenia; and net earnings about 11% higher.

In 2012, there were 376 dwellings per 1,000 population. About 57% of dwellings had at least three rooms. Average size of dwellings in the municipality was 82 m2.

About every other person in Novo mesto had a car (54 passenger cars per 100 population); cars in this municipality were on average 8 years old.

In 2012, 351 kg of municipal waste per person was collected in Novo mesto, which is 24 kg more than on average in Slovenia.